Prostate Cancer Scientific Abstracts - X

Welcome to the Prostate Cancer Guide scientific abstracts, author section X. Here you will find abstracts from the latest research being carried out in the field.

This section is recommended for people who have a scientific interest in prostate cancer. It is recommended that people without prior knowledge of prostate cancer visit the more general areas of this site (Prostate Cancer Guide).

Abstract Authors


Latest Prostate Cancer Abstract

Journal: Prostate Cancer Prostatic Diseases

Issue: 2006, May

Pubmed ID: 16683014

Authors: Xu K, Ling MT, Wang X, Wong YC.

Title: Evidence of a novel biomarker, alphas1-Casein, a milk protein, in benign prostate hyperplasia.

Benign prostate hyperplasia is a common disease in elderly men. Although it is a non-malignant disease, it has a significant detrimental impact on the quality of life in patients with late-stage disease. Owing to the lack of specific markers, diagnosis of early-stage benign prostate hyperplasia has been proven unsuccessful. Recently, using two-dimensional electrophoresis, we identified a group of prostatic secretory proteins that are specifically produced by benign prostate hyperplasia cells (Xu et al., Electrophoresis 2003; 24: 1311). In this study, we investigated the potential diagnostic value of one of the secretory proteins, alphas1-Casein, in benign prostate hyperplasia by inmmunohistological staining of normal, benign prostate hyperplasia and prostate cancer tissues. We found that 90% (20 out of 22) of benign prostate hyperplasia tissues showed moderate to strong alphas1-Casein protein expression whereas none of the normal tissues (0 out of 10) and less than 10% of the prostate cancer tissues (3 out of 30) showed similar staining intensity. Our results suggest that alphas1-Casein may be a potential biomarker for early identification of benign prostate hyperplasia patients.

Contact: Department of Anatomy, Laboratory Block, Faculty of Medicine, The University of Hong Kong, Hong Kong, HKSAR, China

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