Prostate Cancer Scientific Abstracts - U

Welcome to the Prostate Cancer Guide scientific abstracts, author section U. Here you will find abstracts from the latest research being carried out in the field.

This section is recommended for people who have a scientific interest in prostate cancer. It is recommended that people without prior knowledge of prostate cancer visit the more general areas of this site (Prostate Cancer Guide).

Abstract Authors


Latest Prostate Cancer Abstract

Journal: Prostate

Issue: 2006, 66(8):822-30.

Pubmed ID: 16482568

Authors: Uemura H, Hasumi H, Ishiguro H, Teranishi J, Miyoshi Y, Kubota Y.

Title: Renin-angiotensin system is an important factor in hormone refractory prostate cancer.

BACKGROUND: The aim of this study was to perform a comprehensive evaluation of the renin-angiotensin system in prostate cancer.

METHODS: We investigated the expression of renin-angiotensin system components in prostate cancer cells treated with hormonal agents. Real-time PCR data showed the expression of the AT(1) receptor, angiotensin I converting enzyme (ACE), and angiotensin I/II (Ang-I/II) precursor in all 87 prostate tissue samples.

RESULTS: Expression of these genes in hormone refractory prostate cancer (HRPC) was significantly higher than that in normal prostate tissue and untreated prostate cancer tissue. Western blot showed that protein expression of the AT(1) receptor and Ang-I/II was enhanced in LNCaP cells cultivated in steroid-free medium. When LNCaP cells were stimulated with dihydrotestosterone (DHT), estradiol (E2), dexamethasone (DEX), or anti-androgen drugs, protein expression of the AT(1) receptor and Ang-I/II was augmented.

CONCLUSIONS: The present data suggest that prostatic renin-angiotensin system is overexpressed in HRPC tissue, and expression of its components is influenced by several kinds of hormonal stimulation.

Prostate (c) 2006 Wiley-Liss, Inc.

Contact: Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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