Prostate Cancer Scientific Abstracts - M

Welcome to the Prostate Cancer Guide scientific abstracts, author section M. Here you will find abstracts from the latest research being carried out in the field.

This section is recommended for people who have a scientific interest in prostate cancer. It is recommended that people without prior knowledge of prostate cancer visit the more general areas of the site (Prostate Cancer Guide).

Abstract Authors


Latest Prostate Cancer Abstract

Journal: Genes Chromosomes and Cancer

Issue: 2006, 45(7):702-16.

Pubmed ID: 16615098

Authors: Murillo H, Schmidt LJ, Karter M, Hafner KA, Kondo Y, Ballman KV, Vasmatzis G, Jenkins RB, Tindall DJ.

Title: Prostate cancer cells use genetic and epigenetic mechanisms for progression to androgen independence.

Studies on the genetic basis of prostate cancer have lead to mixed results with the only consensus being that prostate cancer is a complex disease. Our goal was to gain insight into potential events involved in the acquisition of the androgen-refractory phenotype in prostate cancer cells regardless of DNA-change dependence. To this end, we examined two LNCaP prostate cancer cell line models of progression-one developed in vivo and one developed in vitro-using molecular cytogenetic and microarray gene expression analyses and extended this investigation of specific events into PCa tumors. The chromosomal changes observed in both in vivo and in vitro androgen-independent cell lines are similar to those seen in prostate cancer during tumor progression. Correspondingly, gene expression analysis showed significant heterogeneity in the genes expressed among androgen-independent cells, but with some common gene expression changes that correlated with the acquired androgen-independent phenotype. Thus, growth conditions under which the cells progress appeared to impact the mechanisms used for progression, albeit within tumor-type-specific pathways. Our findings suggest that a dynamic and adaptable combination of epigenetic and DNA-change-dependent events can be used by prostate cancer cells for the acquisition of the androgen-independent phenotype.

(c) 2006 Wiley-Liss, Inc.

Contact: Urology Research, Mayo Clinic College of Medicine, Rochester, MN.

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