Prostate Cancer Scientific Abstracts - F

Welcome to the Prostate Cancer Guide scientific abstracts, author section F. Here you will find abstracts from the latest research being carried out in the field.

This section is recommended for people who have a scientific interest in prostate cancer. It is recommended that people without prior knowledge of prostate cancer visit the more general areas of the site (Prostate Cancer Guide).

Abstract Authors


Latest Prostate Cancer Abstract

Journal: BJU International

Issue: 2006, 97(6):1190-3.

Pubmed ID: 16686710

Authors: Fukagai T, Namiki TS, Carlile RG, Yoshida H, Namiki M.

Title: Comparison of the clinical outcome after hormonal therapy for prostate cancer between Japanese and Caucasian men.

OBJECTIVE: To investigate the impact of race on the effectiveness of hormonal therapy in patients with prostate cancer, by comparing the outcomes of Caucasian men and Japanese-American men treated with hormonal therapy at one institution.

PATIENTS AND METHODS: Fifty-nine Caucasian men and 105 Japanese-American men with prostate cancer were treated with hormonal therapy at The Queen's Medical Center in Honolulu. Age, stage, Gleason score, race, and pretreatment PSA levels were abstracted. The Kaplan-Meier method was used to construct overall and cause-specific survival curves, which were compared using log-rank statistics. These factors were assessed as to their interdependence and correlation with the clinical course using a Cox proportional hazards regression model.

RESULTS: Although there were no statistical differences in patient background, Japanese-American men who had received hormonal treatment had a better outcome than Caucasian men for overall and cause-specific survival rate (P = 0.001 and 0.036, respectively). Race was one of the significant prognostic factors in the multivariate analysis (P = 0.03). The findings suggest a difference in the effectiveness of hormonal therapy for prostate cancer in Japanese-American men living in Hawaii compared to Caucasian men.

CONCLUSIONS: There were marked racial differences in clinical outcome after hormonal therapy between Japanese-American men and Caucasian men. A prospective study with more patients might be necessary to elucidate the differential effectiveness of hormonal therapy for prostate cancer in different races, especially between Japanese and Caucasians.

Contact: Department of Urology, Showa University School of Medicine, Tokyo, Japan.

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