Prostate Cancer Scientific Abstracts - D

Welcome to the Prostate Cancer Guide scientific abstracts, author section D. Here you will find abstracts from the latest research being carried out in the field.

This section is recommended for people who have a scientific interest in prostate cancer. It is recommended that people without prior knowledge of prostate cancer visit the more general areas of the site (Prostate Cancer Guide).

Abstract Authors

Daher   Dahiya  Dahl  Dahlberg  Dahm  Dahmani  Dahn
Dahnert  Dahut  H. Dai  J.Dai   J.L. Dai  J.M. Dai   J.R. Dai
Q.Dai  Daja  Dakubo  Dal-Farra  Dal-Maso Dal-Moro Dalais

Latest Prostate Cancer Abstract

Journal: Cancer Immunology Immunotherapy.

Issue: 2006 55(8):1025-1032

Pubmed ID: 16506069

Authors: Dalgleish AG, Whelan MA.

Title: Interfering with cell-survival signalling as a treatment strategy for prostate cancer.

The development of cancer vaccines has been one of the several false dawns in which initial promising Phase I and Phase II clinical data have not been followed up with conclusive Phase III trials. In this review, we describe some of the successes and failures, and review the most likely reasons for Phase III failure, such as protocol changes, which are common between Phase II and III, and poorly defined patient groups. Nevertheless, significant survival results have been reported with autologous vaccines for colorectal, renal and, more recently, prostate cancer. In addition, it is becoming evident that immunotherapy is potentially synergistic with other treatment modalities, such as chemotherapy, which can reduce T-regulatory activity that inhibits the immune response to cancer vaccines. This potential for synergy should allow cancer vaccines to become part of the standard treatment regimen for many common tumours.

Contact: Department of Oncology, St. George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK, dalgleis@sgul.ac.uk.